Synthesis of Gentiooligosaccharides of Genistein and Glycitein and Their Radical Scavenging and Anti-Allergic Activity

نویسندگان

  • Kei Shimoda
  • Naoji Kubota
  • Hiroki Hamada
چکیده

The synthesis of gentiooligosaccharides of genistein and glycitein using cultured cells of Eucalyptus perriniana as biocatalysts was investigated. The cells of E. perriniana glycosylated genistein and glycitein to give the corresponding 4'-O-β-glucosides, 7-O-β-glucosides, and 7-O-β-gentiobiosides, which were two new compounds. The β-glucosides of genistein and glycitein showed 2,2-diphenyl-1-picrylhydrazyl (DPPH) free-radical scavenging activity and superoxide-radical scavenging activity. On the other hand, 7-O-β-glucosides of genistein and glycitein and the 7-O-β-gentiobioside of glycitein exerted inhibitory effects on IgE antibody production.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Synthesis of beta-maltooligosaccharides of glycitein and daidzein and their anti-oxidant and anti-allergic activities.

The production of beta-maltooligosaccharides of glycitein and daidzein using Lactobacillus delbrueckii and cyclodextrin glucanotransferase (CGTase) as biocatalysts was investigated. The cells of L. delbrueckii glucosylated glycitein and daidzein to give their corresponding 4'- and 7-O-beta-glucosides. The beta-glucosides of glycitein and daidzein were converted into the corresponding beta-malto...

متن کامل

Anti-Alzheimer and Antioxidant Activity of Celastrus paniculatus Seed

        The crude methanolic extract of the seeds of Celastrus paniculatus along with its organic soluble fractions were tested for their possible antioxidant and anti-alzheirmer (AD) activity. The extracts showed prominent DPPH free radical scavenging activity, inhibiting activity of authentic peroxynitrite (ONOO-) and inhibition of total reactive oxygen species (ROS) generation. In D...

متن کامل

Total Phenolic and Flavonoids Contents, Radical Scavenging Activity and Green Synthesis of Silver Nanoparticles by Laurus nobilis L. Leaves Aqueous Extract

In this project, total phenolic and flavonoid contents of the aqueous extract of Laurus nobilis L. leaves were evaluated by colorimetric methods. These natural products which are found in plants extracts, can be considered as reducing and stabilizing agents in the synthesis of metal nanoparticles. Regarding to high amounts of these compounds in the extract, silver nanoparticles were synthesized...

متن کامل

Design and synthesis of new esters of terpenoid alcohols as 15-lipoxygenase inhibitors

Objective(s): 15-Lipoxygenases are one of the iron-containing proteins capable of performing peroxidation of unsaturated fatty acids in animals and plants. The critical role of enzymes in the formation of inflammations, sensitivities, and some cancers has been demonstrated in mammals. The importance of enzymes has led to the development of mechanistic studies, product analysis, and synthesis of ...

متن کامل

On the radical scavenging activity of isoflavones: thermodynamics of O-H bond cleavage.

We have performed Density Functional Theory B3LYP/6-311++G** calculations of reaction enthalpies of antioxidant action mechanisms for nine isoflavones. O-H bond dissociation enthalpies, ionization potentials, proton dissociation enthalpies, proton affinities and electron transfer enthalpies related to Hydrogen Atom Transfer (HAT), Single Electron Transfer-Proton Transfer (SET-PT) and Sequential...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:

دوره   شماره 

صفحات  -

تاریخ انتشار 2011